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According to a new study by a University of Maryland researcher, a new study has found that there are significant bacteriological changes in the intestines of babies at risk for celiac disease that can lead to the development of autoimmune disorders.

Using advanced genome sequencing techniques, researchers, including Rita Colwell, a professor at the University of Honor, found clear changes in the molecular components of several types of microorganisms, cells, and tissues in children who developed celiac disease, which was absent in at-risk children. :

The results of the study, published on July 12 Scientific Bulletin of the National Academy of Sciences, can lead to more effective treatment and prevention of celiac disease.

“These results show that sterilization can be a powerful indicator of celiac disease,” said Colwell, who is appointed by the University of Maryland Institute for Advanced Computer Research. “It warns before symptoms develop, allowing early intervention. “Stool sterilization can be used to monitor newborns, and a change in diet may be sufficient to treat or prevent the disease.”

Celiac disease is a serious autoimmune condition in which gluten consumption causes damage to the small intestine. It is estimated to affect one in every 100 people worldwide.

Colwell և’s research team followed the intestinal microbiota from birth to 500 children at 10 years of age as MassGeneral Children for Children (MGHfC) celiac disease, genomic, microbiome-metabolic examination (CDGEMM). They began collecting large-scale blood fecal samples, along with environmental data on participants, in 2014. Using metagenomic analysis, the researchers linked bacterial composition to function, highlighting changes that were associated with either increased inflammatory processes or reduced inflammation. An important part of the body’s immune response is inflammation, which is a significant cause of celiac disease symptoms.

For the new article, the team compared the intestinal microbiome of 10 infants in the CDGEMM study who continued to develop celiac disease with the intestinal microbiome of 10 infants in the study. All 20 were genetically predisposed to developing celiac disease.

“We found significant changes in the gut microbes, in the pathways, in the metabolites 18 months before the onset of the disease, which was confirmed by positive laboratory tests,” said Maureen Leonard, clinical director at the Center for Cell Research and Treatment. At MGHfC. “It was much earlier than we expected.”

The changes found by the researchers included an increase in anti-inflammatory microorganisms և a decrease in protective և anti-inflammatory microorganisms at different times before the onset of the disease.

Colwell said the study demonstrates the power of next-generation sequencing, combined with bioinformatics, to detect these potential changes. It is partially supported by the National Institutes of Health, National Institute of Diabetes, Digestive and Kidney Disease Research, Harvard Nutrition Research Center, Thrasher Research Foundation, Mucosal Immunology Research Center, Biology Research Center, Massachusetts General Hospital. և Hugh McCormick.

According to the paper’s senior author, Alessio Fasano, MD, director of the Celiac Research and Treatment Center, the approach used by the team will help researchers develop similar studies to diagnose and treat different conditions in which bacteria can play a pathogenic role.

If confirmed by larger databases, these results may provide specific therapeutic targets for the possible prevention of disease perception and the development of celiac disease through preoperative sterilization manipulation.

This story is adapted from a text provided by MassGeneral Hospital for Children.

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