According to future research, assisted reproductive technology (ART) babies are no longer at risk for cancer.
Compared to infertile mothers who did not use ART, children who underwent ART, such as in vitro fertilization (IVF), did not have a higher risk of cancer (HR 0.98, 95% CI 0.79-1.22), according to the University of Amsterdam Medical Center. թեկնածու Mandy Spaan, PhD, from the Netherlands Cancer Institute.
As shown during his presentation at the annual meeting of the European Society of Human Reproduction and Embryology, the risk of cancer was slightly higher in children whose mothers had intracytoplasmic sperm injection (ICSI) or frozen embryo transfer, but the increase was not significant.
In addition, he and his colleagues concluded that children pregnant with ART did not have a higher risk of cancer than the general population (standardized frequency ratio 0.98, 95% CI 0.81-1.11).
In a press release, Spaan called the results “quite encouraging, especially for children conceived by fertility,” adding that the results add insight into the health risks of ART for generations to come.
There is growing evidence that fertilization can prevent genetic changes in the embryo before implantation, Spaan explained, noting that fertility drugs, embryo thawing, freezing, and the environment in which the embryos grow can all have an effect, although further studies are needed.
He said the findings would help clinicians provide couples seeking fertility treatment with information about the health risks of future generations by providing them with “evidence of a link between the risk of cancer in children and adolescents”.
The researchers analyzed data from the Netherlands-based OMEGA Consortium, a nationwide study with promising implications. The study included children born between 1983 and 2012 who were treated at one of the 13 IVF clinics or at two regional fertility centers.
The team received data on maternity treatment և maternity questionnaires from medical records, the Dutch Perinatal Register, maternity questionnaires, and information on cancer cases from the Netherlands Cancer Registry.
Of the more than 98,000 live births, about 53,000 became pregnant through ART. In total, 382 cancers were observed. 166 in the mesh group, և 222 in the non-mesh group. The median age at the end of the study was 17 years, but was shorter in the ART-perceived group than in the non-ART group (16 versus 19), the researchers said.
Babies born to mothers with ICSI had a higher risk of cancer (HR 1.20, 95% CI 0.85-1.70) than those whose mothers received frozen embryo transfer (HR 1.25, 95% CI 0.68-2.43), but the results were significant. were not. Spaan noted that four cases of melanoma were reported in ICSI children, which may have been accidental.
There is no specific risk of cancer in ART infants compared to the general non-ART population. Compared with the non-ART group, ART children also did not have a higher risk of lymphoblastic leukemia (HR 1.03, 95% CI 0.58-1.82).
At 18 years after ART, the risk of cancer in children was 1.22 (95% CI 0.86-1.74), he said.
Spaan acknowledged that the incidence of cancer in this population is low, which may have limited results from subgroup analyzes, particularly the link between site-specific cancers and embryo transfer.
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